Search results for "BINDING PEPTIDES"

showing 2 items of 2 documents

The symbiosis between Nicotiana tabacum and the endomycorrhizal fungus Funneliformis mosseae increases the plant glutathione level and decreases leaf…

2015

Over time, anthropogenic activities have led to severe cadmium (Cd) and arsenic (As) pollution in several environments. Plants inhabiting metal(loid)-contaminated areas should be able to sequester and detoxify these toxic elements as soon as they enter roots and leaves. We postulated here that an important role in protecting plants from excessive metal(loid) accumulation and toxicity might be played by arbuscular mycorrhizal (AM) fungi. In fact, human exploitation of plant material derived from Cd- and As-polluted environments may lead to a noxious intake of these toxic elements; in particular, a possible source of Cd and As for humans is given by cigarette and cigar smoke. We investigated …

AntioxidantPhysiologyNicotiana tabacummedicine.medical_treatmentAM fungi Arsenic Cadmium Cigarettes Glutathione Mycorrhiza Smoking Tobacco ARBUSCULAR MYCORRHIZAL FUNGI PHOSPHATE-UPTAKE SYSTEM HOLCUS-LANATUS L GLOMUS-MOSSEAE PHYTOCHELATIN SYNTHASE TRANSGENIC TOBACCO BINDING PEPTIDES L. TYPES ACCUMULATION TOLERANCEPlant SciencePlant RootsAntioxidantsARBUSCULAR MYCORRHIZAL FUNGIGlomeromycotachemistry.chemical_compoundMycorrhizaeSoil PollutantsMycorrhizaHOLCUS-LANATUS LCadmiumbiologyMedicine (all)SmokingAdaptation PhysiologicalGlutathioneAM fungi; Arsenic; Cadmium; Cigarettes; Glutathione; Mycorrhiza; Smoking; Tobacco; Adaptation; Physiological; Antioxidants; Glomeromycota; Mycorrhizae; Plant Leaves; Plant Roots; Soil Pollutants; Stress; Symbiosis; Plant Science; Genetics; Physiology; Medicine (all)AM fungiBINDING PEPTIDESCadmiumSettore BIO/07 - EcologiaGLOMUS-MOSSEAEPhysiologicalchemistry.chemical_elementPHYTOCHELATIN SYNTHASEFungusStressAM fungi; arsenic; cadmium; cigarettes; glutathione; mycorrhiza; smoking; tobaccoArsenicSymbiosisStress PhysiologicalBotanyTobaccomedicineGeneticsTOLERANCEAdaptationGlomeromycotaSymbiosisACCUMULATIONCigarettesfungiL. TYPESGlutathionebiology.organism_classificationPHOSPHATE-UPTAKE SYSTEMTRANSGENIC TOBACCOPlant LeaveschemistryMycorrhiza
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Specific Zn(II)-binding site in the C-terminus of Aspf2, a zincophore from Aspergillus fumigatus

2022

Abstract Aspergillus fumigatus, one of the most widespread opportunistic human fungal pathogens, adapts to zinc limitation by secreting a 310 amino acid Aspf2 zincophore, able to specifically bind Zn(II) and deliver it to a transmembrane zinc transporter, ZrfC. In this work, we focus on the thermodynamics of Zn(II) complexes with unstructured regions of Aspf2; basing on a variety of spectrometric and potentiometric data, we show that the C-terminal part has the highest Zn(II)-binding affinity among the potential binding sites, and Ni(II) does not compete with Zn(II) binding to this region. The 14 amino acid Aspf2 C-terminus coordinates Zn(II) via two Cys thiolates and two His imidazoles and…

Binding SitesAspergillus fumigatusZn(II)- and Ni(II)-binding peptidesMetals and AlloysBiophysicsBiochemistryBiomaterialsZincthermodynamicsProtein DomainsChemistry (miscellaneous)zincophorepotentiometryHumansAmino AcidsMetallomics
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